The department hosts both the computer science program and the mathematics program. The programs share a faculty with a passion for their respective subjects, an interest in innovative ways to teach them, and a dedication to fostering undergraduate research.

The mathematics major begins with the introductory sequence, including Calculus (two semesters), Discrete Mathematics, and Introduction to Advanced Mathematics. Later in the curriculum, students take a two-course sequence in either Abstract Algebra or Analysis and choose five additional electives. The electives offered change annually, but some examples of recent electives include Set Theory, Game Theory, and Topology.

The computer science major begins with a two-semester introduction to algorithmic thinking and computer programming, along with a semester of Calculus and a semester of Discrete Mathematics. Students then take three intermediate courses, including Programming Practicum, Algorithms, and Computing Systems Organization. Following that, students choose from a variety of electives, such as Artificial Intelligence, Theory of Computation, Computer Architecture, Operating Systems, and Software Engineering.

In addition, the department welcomes students choosing to minor in mathematics or computer science. Both disciplines connect strongly with many other concentrations of study.

The department has a long history of fostering undergraduate research. The centerpiece is the Senior Capstone Experience, required of all students majoring in either discipline. Each participant selects a research question, with the help of a faculty mentor, studies that question over the senior year, and develops a public oral presentation and a thesis paper summarizing the results. Often, students also choose to present their research papers at regional and national conferences, such as the Hendrix-Rhodes-Sewanee Mathematics Symposium or the National Conferences for Undergraduate Research. Additionally, many students choose to participate in research during their summers, either at Hendrix College or at another research facility.

The third floor of J. H. Reynolds houses the department. Thoroughly renovated in 2000, the facilities include two computer laboratories, two classrooms, a lounge area for study and discussion, and faculty offices. The department maintains its own network of Linux computers.